It is hard to escape CBD at the moment. 

According to, in an article they wrote in February 2020, they expect the CBD market to grow at a CAGR of roughly 38% over the next five years.

And with so many brands coming out with different CBD products, it’s not a big surprise that more people are trying to work out if it’s something that’s going to work for them.

And the fact is that CBD does have a lot of positive effects for many people. Although most of these are anecdotal, you can safely say that CBD has an impact on chronic pain illnesses, acne, eczema, and sleep. Many people actually take CBD to help them with anxiety too. Or even depression. It’s another fact that in the US, mental illness is affecting 40 million adults over the age of 18, so CBD is often something they will turn to.  

So is it really any wonder that people are looking for natural alternatives to pharmaceuticals?

Not really. It seems like the next logical step.

But like with everything you add to your diet, you need to understand how it is going to react with other substances that you might take. Most often, if you have to take antibiotics, your doctor will advise you not to drink. This is because the interaction of alcohol and antibiotics can result in some serious side effects. in other words, it’s going to make you feel terrible, and you could end up in the hospital. It’s all bad news, so it’s best to avoid it.

But surely when you’re adding something natural into your diet, you should be more relaxed? Well, actually no. Pharmaceutical medications are typically chemically balanced. This means when you add something into your system as CBD can potentially tip the scale.

Even with a CBD, there can be some adverse reactions with a range of drugs.

Related: How Long Does CBD Stay in Your System?

What Are Some Common Drugs To Avoid With CBD?

Monday to Friday medicine pills

It’s important to note that when you are talking about CBD drug interactions, it can either result in dangerous side effects or cause minute symptoms.  

Clobazam and valproic acid

There are a few drugs that should never be taken with CBD oils or CBD dietary supplements. Two of those are clobazam and valproic acid. For the latter, valproic acid, combined with CBD, can cause significant injuries to your liver. When CBD is mixed with clobazam, it could intensify the effects of the drug and its levels, which can lead to toxicity.


Warfarin is another drug that should not be used with CBD. Warfarin has a super narrow therapeutic window, so even small changes to the anticoagulants in your body can increase the risk of bleeding and thrombosis. Both CBD and THC can inhibit the metabolic activity of the CYP2C9 enzymes, therefore, increase the risk of bleeding. 


Theophylline is a bronchodilator; which is used to treat symptoms of bronchitis, emphysema, lung disease, and asthma. It has been shown that smoking marijuana might have an impact on the metabolic clearance of theophylline, which can lower the drug’s therapeutic effect. 

It is not clear whether the interaction comes directly from cannabis or simply from smoking marijuana. However, there has been no direct link between another form of cannabinoid that induces the clearance of theophylline in the body.

Other List of Medications to Avoid With CBD

Some prescription medications will require precaution and knowledge that there could be a potential interaction. These drugs either decrease or increase how quickly the liver enzymes can break down the substance. This means it has a direct impact on reducing or intensifying their effects.

You will actually notice that most of these drugs have CYP450s enzymes. The Cytochrome P-450 enzyme system is what metabolizes potentially toxic compounds in the body.

If you happen to be taking anything that falls into that category, you will need to consult a medical professional before you consider CBD. Here is a rough list to guide you: 

  • Steroids
  • HMG CoA reductase inhibitors
  • Calcium channel blockers
  • Antihistamines
  • Prokinetics
  • HIV antivirals
  • Immune modulators
  • Benzodiazepines
  • Antiarrhythmics
  • Antibiotics
  • Anesthetics
  • Antipsychotics
  • Antidepressants
  • Anti-epileptics
  • Beta-blockers
  • PPIs
  • NSAIDs
  • Angiotensin II blockers
  • Oral hypoglycemic agents
  • Sulfonylureas

Related: Promising CBD Research Results



This might sound a little bit strange, but it’s not full-proof. Harvard Medical School indicated that CBD could increase the level of the coumadin in your blood. Not only that, but it can raise the levels of certain medications in your blood by the exact same mechanism as grapefruit. 

If you are unable to drink grapefruit when you are taking any of your prescription medications, it is highly likely that you are unable to take CBD as well.

Related: CBD Isolates: Everything You Need to Know


There is a lot of science to back up the safety profile of CBD. There has been a study after study showing that CBD is very well tolerated and generally safe to use for everyone, from pets to adults. And at the same time, it rarely produces serious side-effects by itself. However, CBD is a compound that does have a profound impact on a wide range of systems within the body, which is from the Endocannabinoid system. This system is entirely designed for the homeostasis of your body, and when something like CBD has an impact on that, it can change the effects and levels of your medication.

CBD is similar to anything you add into your body in terms of vitamins, minerals, and other drugs. However, it’s vital to talk to your medical professional if you do happen to be on any medication that falls within the CYP enzyme category. 

They will be able to give you a range of information regarding the dose of CBD that will be effective without causing any adverse effects. This might mean, in some cases, starting at a lower dose of CBD and gradually moving to a higher dose. 

Keep in mind that it’s also essential to purchase quality CBD products, especially from Black Rain that has a wide variety of selection. Contact Us today for more information!